Abstract
Background Anaplastic carcinoma of the thyroid (ATC) is the most aggressive thyroid gland malignancy. Although ATC accounts for less than 2% of all thyroid cancers, it causes up to 40% of deaths from thyroid cancer. Anaplastic carcinoma consists partly or entirely of undifferentiated cells. This represents 10% of all thyroid carcinomas and this is the most aggressive neoplasm of this gland.
Objective To estimate the proportion of anaplastic carcinoma and its subtypes.
Methods and Results We studied 150 cases out of which 15 were reported as thyroid malignancy. Anaplastic carcinomas are reported here in four cases of middle age 5th and 6th decay of their life, two male and two female 1:1 with history suggestive of hyperthyroidism in three cases and euthyroid in one case. The tumours were of variable size and showed large pleomorphic cells in clusters as well as in an isolated form. The femaleto-male ratio was approximately 3:1. Peak incidence occurs during the third to fourth decades of life. The age range of affected patients reportedly is 15–70 years.
Conclusion ATC is a very uncommon malignancy but in our study we found four cases and we confirmed it by histopathological examination.
Keywords
References
Davidson HG, Campora RG. The thyroid. In: Bibbo M, editor. Comprehensive Cytopathology, 2nd ed. Philadelphia: WB Saunders Co. 1997; pp 673–674.
Orell SR, Sterrett GF, Walters MN, Whitaker D. Thyroid. In: Manual and Atlas of Fine Needle Aspiration Cytology, 3rd ed. New York: Churchill Livingstone, 1999; pp 110–3.
Stewart J. Fine needle aspiration cytodiagnosis of anaplastic carcinoma and differentiation from papillary and follicular carcinoma. Cytopathology I. 1983;204–8.
Willems JS, Löwhagen T, Palombini L. The cytology of a giantcell osteoclastoma like malignant thyroid neoplasm. A case report. Acta Cytol. 1979;23(3):214–6.
Scheider V, Frable WJ. Spindle and giant cell carcinoma of the thyroid: cytological diagnosis by fine needle aspiration. Acta Cytol. 1980;24(3):184–9.
Ravichander PK, Verma SK, Smile SR. Effectiveness of fine needle aspiration cytology in thyroid lesions in contrast with histopathology. J Cytol. 2000;17(1):33–8.
Gupta C, Sharma VK, Aggarwal AK, Bisht D. Fine needle aspiration cytology of solitary nodule of thyroid and its histopathological correlation. J Cytol. 2001;18(3):151–6.
Maitra A, Abbas AK. The endocrine system. In: Robbins and Cortan, editors. Pathologic Basis of Diseases, 7th ed. Philadelphia: WB Saunders Co., 2004; pp 1164–83.
Corton RS, Kumar V, Robbins SL. In: Robbins Pathological Basis of Disease, 5th ed. New York: WB Saunders Co., 1994; pp 326–8.
Gardiner GW, De Souza FM, Carydis B, Seemana C. Fine-needle aspiration biopsy of the thyroid gland: results of a five-year experience and discussion of its clinical limitations. J Otolaryngol.1986;15:161–5.
Hawkins F, Bellido D, Bernal C, et al. Fine needle aspiration biopsy in the diagnosis of thyroid cancer and thyroid disease. Cancer. 1987;59:1206–9.
Khafagi F, Wright G, Castics H, et al. Screening for thyroid malignancy, role of fine-needle biopsy. Med J Aust. 1988;149:302–3,306–7.
Hall TL, Layfield LJ, Philippe A, Rosenthal DL. Sources of diagnostic error in fine needle aspiration of the thyroid. Cancer. 1989; 63:718–25.
Altavilla G, Pascale M, Nenci I. Fine needle aspiration cytology of thyroid gland disease. Acta Cytol. 1990;34(2):251–6.
Caplan RH, Strutt PJ, Kisken WA, Wester SM. Fine needle aspiration biopsy of thyroid nodules. Wis Med J. 1991;90:285–8.
Gharib H, Goellner JR, Zinsmeister AR, et al. Fine-needle aspiration biopsy of the thyroid. Ann Intern Med. 1984;101(1):25–8.
Mathur SR, Kapila K, Verma K. Role of fine needle aspiration cytology in the diagnosis of goitre. Indian J Pathol Microbiol.2005;48(2):166–9.
Dkhar H, Garg I, Shariff S: Hashimoto’s thyroiditis presenting as a solitary nodule in the thyroid. J Cytol. 2000;17(1):23–5.
Silverman JF, West RL, Laskin EW. The role of fine needle aspiration biopsy in the rapid diagnosis and management of thyroid neoplasm. Cancer. 1986;57:1164–70.
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